ADVANCED NANOCARRIERS FOR DRUG SOLUBILIZATION: A FOCUS ON LIPID-BASED SYSTEMS

Abstract

Nanotechnology has revolutionized medicine, particularly through the advancement of nanomedicine, which has introduced innovative solutions in drug delivery systems. Among these, lipid-based Nano carriers have emerged as promising tools to enhance the solubility, stability, and bioavailability of poorly water-soluble drugs, such as those in the Biopharmaceutical Classification System Class II. These drugs, characterized by low solubility and high permeability, face significant challenges in formulation, primarily due to their poor aqueous solubility, which results in low oral bioavailability. Various strategies have been developed to Prevent these challenges, including solid dispersion and lipid-based systems like liposomes, solid lipid nanoparticles, and self-nanoemulsifying drug delivery systems. Liposomes, for example, are spherical vesicles that can encapsulate both hydrophilic and lipophilic drugs, offering a versatile platform for drug delivery. Furthermore, self-nanoemulsifying systems Enhance the solubility and bioavailability of lipophilic drugs by enhancing their dissolution rate and facilitating lymphatic transport. Another advancement is the use of nanostructured lipid carriers, which combine both solid and liquid lipids to improve drug loading and release properties. The development of these advanced Nano carriers, which include Solid Lipid Nano carriers, sphingolipid-based systems, has demonstrated significant potential in targeted therapy, including applications in cancer treatment and topical drug delivery. By improving drug stability, controlled release, and minimizing side effects, lipid-based Nano carriers represent a transformative approach to precision medicine, with broad implications for enhancing the effectiveness of existing and emerging therapies.

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