UTI Management in the Modern Era: Integrating Novel Therapies and Multifaceted Strategies

Abstract

UTIs are a prevalent microbiological illness that can affect people of all ages and range from a mild case of cystitis to a life-threatening case of uroseptic shock. Multimodal UTI management is required due to the growing problem of antibiotic resistance (AMR) in pathogens such as Escherichia coli and Klebsiella. This review clarifies how the management of UTIs has changed in response to increased AMR and the introduction of new antimicrobial agents. Antibiotics are still essential treatments, but overuse and abuse are progressively reducing their effectiveness. Therefore, promising options for managing UTIs include alternative therapies like acupuncture, natural remedies, live-attenuated vaccinations, and hydration. Moreover, probiotics, natural polyphenols, and nutraceuticals show promise in the management and prevention of UTIs.Novel approaches to treating and preventing urinary tract infections (UTIs) include the use of antimicrobial catheters, antibiotic coatings, colistin, nanoparticles for targeted drug delivery, and nonsteroidal anti-inflammatory drugs (NSAIDs). The therapeutic arsenal against UTIs is further enhanced by the use of bacterial extracts in immunotherapy, estrogens that strengthen the uroepithelium, and the medicinal qualities of plants like black chokeberry and pomegranate. All these methods have different benefits when it comes to preventing UTIs, which emphasizes the need for a comprehensive plan to deal with this common and frequently recurring health issue. In the face of antibiotic resistance, healthcare professionals can improve patient outcomes, minimize treatment failures, and optimize UTI management by integrating diverse modalities.

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