IN VIVO EVALUATION OF GUAR GUM HYDROGEL INCORPORATED POLY-MUSHROOM EXTRACT FOR CHRONIC WOUNDS IN RATS

Abstract

Chronic wounds are widespread. It is estimated that 1 to 2% of the population will experience a chronic wound during their lifetime in both developed and undeveloped countries. Studies in India have reported higher rates of wound infections from 23% to 38% due to chronic wounds. The conventional medicines used for the treatment of chronic wounds are Bacitracin, Neosporin, and Polysporin. Although widely used, serious side effects observed are severe pain, nausea, lack of appetite, significant emotional and physical distress, and lack of sleep. In this context we propose to explore the angiogenic property of poly fungal extracts that are already known for their biological properties such as antitumor, anticancer, antioxidant, and antifungal activities. Guar gum is a biopolymer derived from the seeds of the guar plant. It has been used in a variety of applications, including food, pharmaceuticals, and cosmetics, due to its unique properties such as thickening, stabilizing, and emulsifying. In recent years, guar gum has also been studied for its potential use in tissue regeneration. It is important to note that the use of guar gum hydrogel incorporated with poly mushroom extract for chronic wound treatment in humans has not yet been extensively studied. The study concludes that the poly mushroom extract incorporated with guar gum hydrogel appears to possess extremely good wound healing attributes and can be employed as a potential wound dressing aid and tissue regeneration.

Keywords